Human 3D Tri-Lineage Lung Organoid Model

Idiopathic pulmonary fibrosis (IPF) is a progressive disease with limited treatments and flawed animal models. Leveraging chemically reprogrammed AT2 cells, this project develops a human 3D lung organoid system (alveolar epithelial cells, fibroblasts, macrophages) to recapitulate IPF pathogenesis. It uses multiple assays to evaluate drug responses, aiming for a stable, scalable platform for patient-specific modeling and high-throughput antifibrotic drug screening.